Would you like to participate in a study for Essential Tremor (ET)?

We are inviting you to take part in a study for adults who experience tremors in an upper limb (such as your arms) due to ET. All study-related visits, tests, and investigational medication will be provided at no cost to you. In addition, reimbursement for time and travel may be provided. No health insurance is required.

See if you qualify – Complete the questionnaire

The EveresT Study is researching an investigational medication that may help to decrease tremor severity.

You may qualify for the EVEREST Study if you:

  • Are between the ages of 18 and 80 years old
  • Have Essential Tremor (ET) and experience tremors in your hands or arms
  • Have difficulty performing daily activities such as eating, drinking, dressing, or writing
Participants who take part in the study may receive reimbursement for time and travel.
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For more information about the study, please see the description on ClinicalTrials.gov

Sign Up

What happens if I sign up? We will match you to a study location in your area that needs volunteers with ET or notify you when one becomes available. The study team will then contact you and you may have the opportunity to participate if you qualify.

If you think you might like to participate in the EveresT Study or would like more information, please enter your information below so we can see if you may qualify and can contact you about the study. Keep in mind that participation is entirely voluntary. If you do decide to take part in the study, you may change your mind about participating at any time.

About Essential Tremor (ET)

Essential Tremor is a serious, progressive, and chronically debilitating neurological disorder that can profoundly affect activities of daily living. Essential tremor is considered one of the most common movement disorder among adults.1

Essential Tremor is characterized by an action tremor in the hands and arms that is bilateral (affects both sides of the body) and often slightly unbalanced. The tremor is present during deliberate movement, like reaching for a glass of water or writing, or even while trying to sit still. In patients with ET, tremor may also be present in the head, voice, and jaw, and less commonly the face or torso.2

Essential Tremor has no cure, but some medications can be used to treat symptoms of ET. No marketed drug therapy or medication has been developed specifically for the treatment of Essential Tremor. All currently available drug therapies have limitations with respect to efficacy, safety, or limited evidence from randomized, clinical trials to support their widespread use.3

The EveresT Study is researching the safety and effectiveness of an investigational medication that may help to decrease tremor severity.

References:
[1]
Louis ED and Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Movement Disorders. 2010;25(5):534-41.
[2]
Louis ED. Essential tremor and the cerebellum. In: Handbook of Clinical Neurology 2018; 155:245-258. Elsevier.
[3]
Haubenberger D and Hallett M. Essential tremor. New England Journal of Medicine. 2018;378(19):1802-10.

Find a study center

The interactive map shows the study centers that are actively participating in the Everest Study. You can enter your ZIP Code to find the study center closest to you or email and/or call the study team to learn more. If you qualify for the study, there is no obligation to join — you can decide if you would like to participate.

Please select the study center that is most convenient for you.

Frequently Asked Questions

What is a study?

A study (also called a clinical trial) is a medical study that helps to answer important questions about an investigational medication – these may include how well an investigational medication works for a certain condition. All medications must be tested in clinical research studies before they can be approved and prescribed to patients.

A study is the process by which new and innovative medications, interventions and treatments are approved and brought to the general public, so people can hopefully live happier and healthier lives. Even over-the-counter medications, such as aspirin, you may have used to counteract a headache, have gone through the clinical research study process before it was available at your local pharmacy.

The EveresT Study is researching the safety and effectiveness of an investigational medication to reduce the severity of Essential Tremor when taken once daily for up to 12 weeks.

The total duration of the study for each participant will be approximately 21 weeks. During the Screening Period, which will occur over a period of up to 7 weeks, participants will have tests and procedures to find out if they can take part in the study. Participants will also be asked to stop taking any medications that are not allowed in the study.

If qualified, participants will be randomly assigned, like drawing straws, to 1 of 4 treatment groups. There will be 3 different doses of the investigational medication and 1 group that will take placebo. A placebo looks like the investigational medication but contains an inactive substance that does not directly cause any physical changes to your body.

The treatment period will take 12 weeks to complete and will involve approximately 8 visits to the study site and 8 phone calls from the study team, depending on your country regulations.

Volunteers who qualify to take part in the study may receive reimbursement for time and travel. Please discuss this with the study team when they contact you.

There is no cost to participate in the EveresT Study. If you decide to take part:

  • You will receive study-related care from a team of experienced doctors and nurses throughout the study.
  • All study-related visits, tests, and investigational medication will be provided at no cost to you.

The research team will be able to explain more about what the EveresT Study will involve, and it is up to you to decide if you want to take part. Participation in this study is voluntary. Whether or not you decide to participate in this study will not affect your current or future relationships with your doctors. If you decide to participate, you are free to withdraw at any time without affecting those relationships.

We match you to a study site within a close travel distance from your home. If we are not running the study in your area currently, with your permission, we will keep you in our database and reach out once a study in your area becomes available. If, at any time, you decide you no longer want your information stored, you can opt out and we will delete your details.

About the EveresT Study

The EveresT Study will enroll approximately 400 people at approximately 54 research sites in the United States and Europe.

The study will last about 21 weeks, which includes a 1 to 7 week screening period, a 12 week treatment period, and a 2 week follow-up period. These three periods will involve approximately 8 visits to the study site and 8 phone calls from the study team, depending your country regulations.

Participants will receive all study-related visits, tests, and investigational medication from a dedicated medical team at no cost.

Participants who qualify to take part in the study may receive reimbursement for time and travel.

Who can take part in the EveresT Study?

You may qualify for the EVEREST Study if you:

  • Are between the ages of 18 and 80 years old
  • Have Essential Tremor (ET) and experience tremors in your hands or arms
  • Have difficulty performing daily activities such as eating, drinking, dressing, or writing

All study-related care is provided by specialist physicians.

The EveresT Study is researching the safety and effectiveness of an investigational medication that may help to decrease tremor severity.